[Faculty] Fwd: [CSRC.COLLOQUIUM] CORRECTION: "Engineering Cancer Cell Migration"

[Jose Castillo]

<https://lh3.googleusercontent.com/-ZPFNPh16sR0/Wt39FrXUP-I/AAAAAAAAAaw/3wQunGe20lUopmV_ggfPaDwE9cVAgVzxgCLcBGAs/s1600/image001.jpg>


DATE:  *Friday, October 11, 2019*



TITLE:


*Engineering Cancer Cell Migration*




TIME:  *3:30-4:30PM*




LOCATION:
*GMCS 314*




SPEAKER/BIO:



*Dr. Stephanie Fraley, Assistant Professor of Bioengineering,  *


*University of California-San Diego *




ABSTRACT:

Metastasis is the primary cause of cancer related deaths. The migration of
cancer cells from their tissue of origin to other tissues in the body is
central to the metastatic process. Efforts to control the spread of cancer
will require a predictive understanding of how metastatic migration is
extrinsically and intrinsically regulated. My lab is working to reach this
level of cell migration engineering by addressing three core knowledge
gaps: (1) how is migration differentially regulated by microenvironmental
context, (2) what is the source of migration heterogeneity among cells of
the same type in the same context, and (3) how can we link migration
phenotype to genotype to identify key molecular regulators despite
extensive heterogeneity. We have developed three new approaches to address
these questions. First, to deepen our understanding of migration regulation
by the collagen-rich tumor microenvironment, we have developed a technique
to tune collagen architecture independently of density and stiffness. We
find that collagen architecture regulates oxidative and metabolic stress by
tuning adhesion strength, and that adhesion strength is directly related to
matrix degradation. Next, we integrate four quantitative microscopy
techniques to measure the core processes driving migration simultaneously
in single cells. This is unveiling the way in which subcellular processes
integrate to produce whole cell migration behaviors and is being used to
model and predict migration heterogeneity. Finally, we employ a
photoconversion scheme to enable “laser tagging” of cells based on
migration phenotype for subsequent cell sorting and molecular analysis.
Through this approach, we show that migration-phenotype-based clustering of
single-cell RNA sequencing data reveals unique insight into molecular
regulators of migration as well as the different metabolic and immune
regulatory states of cancer cell subpopulations.


[image: SFraley.jpg]




BIOGRAPHY:

Dr. Stephanie Fraley joined UC San Diego in July 2014 as an assistant
professor of Bioengineering. Her research takes a multidisciplinary and
multi-scale approach to (1) understand mechanisms of cell migration
underlying human disease, in particular cancer, and (2) develop clinical
profiling technologies for improved understanding and treatment of human
diseases. She earned her B.S. in Chemical Engineering in 2006 from The
University of Tennessee Chattanooga and her Ph.D. in Chemical and
Biomolecular Engineering in 2011 from The Johns Hopkins University. For her
graduate work, she was awarded an NSF Graduate Research Fellowship,
National Tau Beta Pi Fellowship, and was an Achievement Rewards for College
Scientists Scholar, Johns Hopkins Heath Fellowship, National Siebel
Scholarship, and ASEE/NSF Engineering Innovations Fellowship. Dr. Fraley
then joined the Emergency Medicine department at The Johns Hopkins
University as a postdoctoral fellow where she developed novel technological
approaches to sensitively detect and quantitatively identify genetic
material circulating in the bloodstream. Recently, she received a National
Burroughs Wellcome Fund Career Award at the Scientific Interface for her
research merging clinical diagnostic and basic research approaches. She is
also a SAGE Bionetworks Scholar, Kavli Frontiers of Science Fellow, BMES
CMB Rising Star awardee, and recipient of an NSF CAREER award.










Host: Parag Katira, Department of Mechanical Engineering

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