<div dir="ltr"><div class="gmail_quote"><div dir="ltr" class="gmail_attr"><br></div><br><br><div dir="ltr"><div><div style="overflow:auto"><div style="max-height:10000px"><div dir="ltr"><div><div style="overflow:auto"><div style="max-height:10000px"><div dir="ltr"><div><div style="overflow:auto"><div style="max-height:10000px"><div dir="ltr"><div><div style="overflow:auto"><div style="max-height:10000px"><div dir="ltr"><div><div style="overflow:auto"><div style="max-height:10000px"><div dir="ltr"><p style="text-align:center;clear:both"><a href="https://lh3.googleusercontent.com/-ZPFNPh16sR0/Wt39FrXUP-I/AAAAAAAAAaw/3wQunGe20lUopmV_ggfPaDwE9cVAgVzxgCLcBGAs/s1600/image001.jpg" style="margin-left:1em;margin-right:1em" target="_blank"><img src="https://lh3.googleusercontent.com/-ZPFNPh16sR0/Wt39FrXUP-I/AAAAAAAAAaw/3wQunGe20lUopmV_ggfPaDwE9cVAgVzxgCLcBGAs/s1600/image001.jpg" border="0"></a></p><br>
<p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black"><br></span></p><p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black">DATE:</span><span style="font-size:10.0pt;font-family:"Verdana",sans-serif;color:black"> </span><span style="font-size:13.5pt;font-family:"Verdana",sans-serif;color:black"> </span><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif">Friday, October 11, 2019</span></b></p><p class="MsoNormal" style="text-align:center" align="center"><span style="font-size:10.0pt;font-family:"Verdana",sans-serif;color:black"></span></p>
<p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black"><br></span></p><div dir="ltr"><p class="MsoNormal" style="text-align:center" align="center"><span style="font-size:10.0pt;font-family:"Verdana",sans-serif;color:black"></span></p>
<p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black"><br></span></p><p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black">TITLE:</span><span style="font-size:10.0pt;font-family:"Verdana",sans-serif;color:black"> <br></span></p><p class="MsoNormal" style="text-align:center" align="center"><span style="font-size:10.0pt;font-family:"Verdana",sans-serif;color:black"> <br></span></p><p class="MsoNormal" style="text-align:center" align="center"><font size="6"><span style="font-family:verdana,sans-serif"></span></font></p><p class="MsoNormal" style="text-align:center" align="center"><font size="6"><span style="font-family:verdana,sans-serif"><b><span style="background:white none repeat scroll 0% 0%"></span></b></span></font></p><div style="text-align:center"><span style="font-family:verdana,sans-serif"><font size="6"><b><span></span></b></font></span><span style="font-family:verdana,sans-serif"><font size="6"><b><span></span></b></font></span><span style="font-family:verdana,sans-serif"><font size="6"><b><span></span></b></font></span><span style="font-family:verdana,sans-serif"><font size="6"><b><span></span></b></font></span><span style="font-family:verdana,sans-serif"><font size="6"><b><span></span></b></font></span><span style="font-family:verdana,sans-serif"><font size="6"><b><span></span></b></font></span><span style="font-family:verdana,sans-serif"><font size="6"><b><span></span></b></font></span><span style="font-family:verdana,sans-serif"><font size="6"><b><span></span></b></font></span><span style="font-family:verdana,sans-serif"><font size="6"><b><span></span></b></font></span><span style="font-family:verdana,sans-serif"><font size="6"><b><span> </span></b></font></span><span style="font-family:verdana,sans-serif"><font size="6"><b><span><span><span>Engineering Cancer Cell Migration</span></span></span></b></font></span><span style="font-family:verdana,sans-serif"><font size="6"><b><span><span><span>
</span></span></span></b></font></span><p class="MsoNormal" style="text-autospace:none"><b><span style="font-size:11.0pt;font-family:"Arial",sans-serif;color:black"><br></span></b></p>
<span style="font-family:verdana,sans-serif"><font size="6"><b><span><span><span></span></span></span></b></font></span><span style="font-family:verdana,sans-serif"><font size="6"><b><span><span><span><span style="font-size:12.0pt;font-family:"Times New Roman",serif"></span></span> </span></span></b></font></span><span style="font-family:verdana,sans-serif"><font size="6"><b><span><span></span></span></b></font></span><span style="font-family:verdana,sans-serif"><font size="6"><b><span style="font-size:11pt"></span></b> </font></span></div><p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black"></span></p>
<p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black"><br></span></p><p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black"><br></span></p><p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black">TIME:</span><span style="font-size:10.0pt;font-family:"Verdana",sans-serif;color:black"> </span><span style="font-size:13.5pt;font-family:"Verdana",sans-serif;color:black"> </span><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif">3:30-4:30PM<span style="color:black"></span></span></b></p>
<p class="MsoNormal" style="text-align:center" align="center"><span style="font-size:10.0pt;font-family:"Verdana",sans-serif;color:black"> </span></p>
<p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black"><br></span></p><p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black">LOCATION:</span><span style="font-size:10.0pt;font-family:"Verdana",sans-serif;color:black"> <b> </b></span><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif">GMCS 314<br></span></b></p>
<p class="MsoNormal" style="text-align:center" align="center"><span style="font-size:10.0pt;font-family:"Verdana",sans-serif;color:black"> </span></p>
<p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black"><br></span></p><p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black">SPEAKER/BIO:</span><span style="font-size:13.5pt;font-family:"Verdana",sans-serif;color:black"> </span><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif"><br></span></b></p><p class="MsoNormal" style="text-align:center" align="center"><br><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif"></span></b></p><p class="MsoNormal" style="text-align:center" align="center"><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif"></span></b><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif"></span></b><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif"></span></b><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif">Dr. Stephanie Fraley, Assistant Professor of Bioengineering, <br></span></b></p><p class="MsoNormal" style="text-align:center" align="center"><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif">University of
California-San Diego <br></span></b><font size="4"><span style="font-family:verdana,sans-serif"><b><span><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif"><span style="color:black"></span></span></b></span><span></span></b></span></font></p><p class="MsoNormal" style="text-align:center" align="center"><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif"></span></b></p>
<p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black"> </span></p>
<p class="MsoNormal"><font size="2"><span style="font-family:"Verdana",sans-serif;color:black"><br></span></font></p><p class="MsoNormal" style="text-align:left"><font size="4"><span style="font-family:"Verdana",sans-serif;color:black">ABSTRACT:</span></font></p><font size="4">
</font><p class="MsoNormal" style="margin-top:0in;margin-right:5.2pt;margin-bottom:0in;margin-left:0in;margin-bottom:.0001pt;line-height:107%">
</p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:11.0pt;font-family:"Arial",sans-serif;color:black"><span style="font-family:verdana,sans-serif"><font size="4"><span style="font-family:arial,sans-serif">
</span></font></span></span></p><p class="MsoNormal" style="text-autospace:none">
</p><p class="MsoNormal"><font size="4"><span style="color:black">Metastasis is the primary
cause of cancer related deaths. The migration of cancer cells from their tissue
of origin to other tissues in the body is central to the metastatic process.
Efforts to control the spread of cancer will require a predictive understanding
of how metastatic migration is extrinsically and intrinsically regulated. My
lab is working to reach this level of cell migration engineering by addressing
three core knowledge gaps: (1) how is migration differentially regulated by microenvironmental
context, (2) what is the source of migration heterogeneity among cells of the
same type in the same context, and (3) how can we link migration phenotype to
genotype to identify key molecular regulators despite extensive heterogeneity.
We have developed three new approaches to address these questions. First, to
deepen our understanding of migration regulation by the collagen-rich tumor
microenvironment, we have developed a technique to tune collagen architecture
independently of density and stiffness. We find that collagen architecture
regulates oxidative and metabolic stress by tuning adhesion strength, and that
adhesion strength is directly related to matrix degradation. Next, we integrate
four quantitative microscopy techniques to measure the core processes driving
migration simultaneously in single cells. This is unveiling the way in which
subcellular processes integrate to produce whole cell migration behaviors and
is being used to model and predict migration heterogeneity. Finally, we employ
a photoconversion scheme to enable “laser tagging” of cells based on migration
phenotype for subsequent cell sorting and molecular analysis. Through this
approach, we show that migration-phenotype-based clustering of single-cell RNA
sequencing data reveals unique insight into molecular regulators of migration as
well as the different metabolic and immune regulatory states of cancer cell
subpopulations. </span></font></p>
<span style="font-size:11.0pt;font-family:"Arial",sans-serif;color:black"><span> </span><span> <br></span></span><p style="text-align:center;clear:both"><img style="margin-left:1em;margin-right:1em" src="https://groups.google.com/a/sdsu.edu/group/csrc.colloquium/attach/50dc06fe0c5e0/SFraley.jpg?part=0.1&view=1&authuser=0" alt="SFraley.jpg" width="400" height="266"></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:11.0pt;font-family:"Arial",sans-serif;color:black"><span style="font-family:verdana,sans-serif"><font size="4"><span style="font-family:arial,sans-serif"></span></font></span></span><br><span style="font-size:11.0pt;font-family:"Arial",sans-serif;color:black"><span style="font-family:verdana,sans-serif"><font size="4"><span style="font-family:arial,sans-serif"></span></font></span></span><span style="font-size:11.0pt;font-family:"Arial",sans-serif;color:black"><span style="font-family:verdana,sans-serif"><font size="4"><span style="font-family:arial,sans-serif">
</span><span></span></font></span></span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:11.0pt;font-family:"Arial",sans-serif;color:black"><span style="font-family:verdana,sans-serif"><font size="4"><span><br></span></font></span></span></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:11.0pt;font-family:"Arial",sans-serif;color:black"><span style="font-family:verdana,sans-serif"><font size="4"><span>
</span></font></span></span></p><p class="MsoNormal" style="text-autospace:none"><font size="4"><b><span style="font-size:11pt;color:black"><br></span></b></font></p><font size="4">
<p class="MsoNormal"><span style="font-family:arial,sans-serif"><span style="color:black">BIOGRAPHY:</span></span></p></font><p class="MsoNormal"><font size="4"><span style="font-family:arial,sans-serif"><span style="color:black"><span style="font-family:"Arial",sans-serif;color:black">Dr.
Stephanie Fraley joined UC San Diego in July 2014 as an assistant professor of
Bioengineering. Her research takes a multidisciplinary and multi-scale approach
to (1) understand mechanisms of cell migration underlying human disease, in
particular cancer, and (2) develop clinical profiling technologies for improved
understanding and treatment of human diseases. She earned her B.S. in Chemical
Engineering in 2006 from The University of Tennessee Chattanooga and her Ph.D. in
Chemical and Biomolecular Engineering in 2011 from The Johns Hopkins
University. For her graduate work, she was awarded an NSF Graduate Research
Fellowship, National Tau Beta Pi Fellowship, and was an Achievement Rewards for
College Scientists Scholar, Johns Hopkins Heath Fellowship, National Siebel
Scholarship, and ASEE/NSF Engineering Innovations Fellowship. Dr. Fraley then
joined the Emergency Medicine department at The Johns Hopkins University as a
postdoctoral fellow where she developed novel technological approaches to
sensitively detect and quantitatively identify genetic material circulating in
the bloodstream. Recently, she received a National Burroughs Wellcome Fund
Career Award at the Scientific Interface for her research merging clinical diagnostic
and basic research approaches. She is also a SAGE Bionetworks Scholar, Kavli
Frontiers of Science Fellow, BMES CMB Rising Star awardee, and recipient of an
NSF CAREER award.</span></span></span></font></p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:11.0pt;font-family:"Arial",sans-serif;color:black"><span style="font-family:verdana,sans-serif"><font size="4"><span></span></font></span></span></p><p class="MsoNormal" style="text-autospace:none"><font size="4"><b><span style="font-size:11.0pt;font-family:"Arial",sans-serif;color:black"><br></span></b></font></p><font size="4">
<p class="MsoNormal" style="text-autospace:none"><span style="font-size:11.0pt;font-family:"Arial",sans-serif;color:black"><br></span></p>
</font><span><font size="4"> </font> </span><p class="MsoNormal" style="margin-top:0in;margin-right:5.2pt;margin-bottom:0in;margin-left:0in;margin-bottom:.0001pt;line-height:107%"><br>
</p><span style="font-family:arial,sans-serif"><font size="4">
</font></span><p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:10.0pt"><span style="font-family:arial,sans-serif"><font size="4"><span> </span></font></span></p></div><br><div dir="ltr"><font size="2"><span style="font-family:verdana,sans-serif"><span style="font-family:"Verdana",sans-serif;color:black"></span></span></font></div><br><div dir="ltr"><br><font size="4"><span style="font-family:verdana,sans-serif"></span><span style="font-family:verdana,sans-serif"></span></font></div><font size="4"><span style="font-family:verdana,sans-serif">Host: </span><span>Parag Katira, Department of Mechanical Engineering<br></span></font></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div>
<p></p>
-- <br>
You received this message because you are subscribed to the Google Groups "CSRC Colloquium" group.<br>
To unsubscribe from this group and stop receiving emails from it, send an email to <a href="mailto:csrc.colloquium+unsubscribe@sdsu.edu" target="_blank">csrc.colloquium+unsubscribe@sdsu.edu</a>.<br>
To view this discussion on the web visit <a href="https://groups.google.com/a/sdsu.edu/d/msgid/csrc.colloquium/fbe96ac3-974f-4f3f-ac66-9eeb458dec15%40sdsu.edu?utm_medium=email&utm_source=footer" target="_blank">https://groups.google.com/a/sdsu.edu/d/msgid/csrc.colloquium/fbe96ac3-974f-4f3f-ac66-9eeb458dec15%40sdsu.edu</a>.<br>
</div></div>