[Faculty] Fwd: [SDSU-CSRC COLLOQUIUM]: "Lipase: An Enzyme at Sea-Spray Aerosol Particle Surfaces?"

[Jose Castillo]

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https://adminlb.imodules.com/s/997/images/editor/csrc-alumni/csrcbanner_jpg.jpg]

DATE:  *Friday, **February 2, 2018*



TITLE:    *Lipase: An Enzyme at Sea-Spray Aerosol Particle Surfaces?*



TIME:  *3:30PM*



LOCATION:  *GMCS 314*



SPEAKER:
*Jamie Schiffer, Ph.D,       Department of Chemistry, UC San Diego*



ABSTRACT:

Sea-spray aerosols (SSA) represent one of the most abundant aerosols within
our atmosphere, and yet the current uncertainties associated with SSA
impacts on total radiative forcing are much larger than those for
greenhouse gases. Recently, it has been shown that triacylglycerol lipases,
hydrolytic enzymes that breakdown lipids into fatty acids, are present and
active within SSA. These enzymes are highly amphiphillic and thus likely to
partition to air-liquid surfaces. If lipase is present at the SSA surface,
then lipase could participate in critical chemical pathways within SSA,
essentially guiding the climate relevant properties of these aerosols.
However, the degree to which lipases partition to air-liquid surfaces as a
function of surface lipid composition, pH and surface pressure, all surface
characteristics which vary between SSA particles, remains elusive.
Moreover, the atomic-level structures of lipases at these surfaces, which
could inform on how lipases alter SSA chemical pathways, are unknown. To
uncover if lipase is present at SSA surfaces and determine the structure of
lipase at these surfaces, surface adsorption isotherms of lipase injected
into Langmuir monolayers of lipids were interpreted in the context of
microseconds of all-atom molecular dynamics simulations of lipase imbedded
in SSA-relevant surfaces. At this talk, the findings from this
collaborative study will be presented and multiscale models for future
study will be considered for studying lipase at SSA surfaces.



HOST: Andrew Cooksy



Dr. Jose E. Castillo
Director/Professor
Computational Science Research Center
5500 Campanile Drive
San Diego State University
San Diego, CA  92182-1245
(619) 59407205/3430, FAX (619) 594-2459



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SDSU Computational Science Research Center
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-- 

Jose E. Castillo  Ph.D.

Director / Professor

Computational Science Research Center

5500 Campanile Dr

San Diego State University

San Diego CA 92182-1245

619 5947205/3430, Fax 619-594-2459

 http://www.csrc.sdsu.edu/mimetic-book/
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