<div dir="ltr"><div class="gmail_quote"><br><br><br><br><div lang="EN-US" link="blue" vlink="purple"><div class="m_-6175594226004111878WordSection1"><p class="MsoNormal" align="center" style="text-align:center"><span style="font-size:12.0pt;font-family:"Times New Roman","serif""> <img width="1017" height="115" id="m_-6175594226004111878Picture_x0020_1" src="cid:image001.jpg@01D3524E.E54B7250" alt="https://adminlb.imodules.com/s/997/images/editor/csrc-alumni/csrcbanner_jpg.jpg"><u></u><u></u></span></p><p class="MsoNormal" align="center" style="text-align:center"><span style="font-size:12.0pt;font-family:"Verdana","sans-serif";color:black">DATE:</span><span style="font-size:10.0pt;font-family:"Verdana","sans-serif";color:black"> </span><span style="font-size:13.5pt;font-family:"Verdana","sans-serif";color:black"> <b>Friday, </b></span><b><span style="font-size:13.5pt;font-family:"Verdana","sans-serif"">February 2<span style="color:black">, 2018</span></span></b><span style="font-size:12.0pt;font-family:"Times New Roman","serif""><u></u><u></u></span></p><p class="MsoNormal" align="center" style="text-align:center"><span style="font-size:10.0pt;font-family:"Verdana","sans-serif";color:black"> </span><span style="font-size:12.0pt;font-family:"Times New Roman","serif""><u></u><u></u></span></p><pre style="text-align:center"><span style="font-size:12.0pt;font-family:"Verdana","sans-serif";color:black">TITLE:</span><span style="font-family:"Verdana","sans-serif";color:black"> </span><b><span style="font-size:13.5pt;font-family:"Verdana","sans-serif""> </span></b><span>  </span><b><span style="font-size:14.0pt;font-family:"Verdana","sans-serif"">Lipase: An Enzyme at Sea-Spray Aerosol Particle Surfaces?</span></b><b><span style="font-size:14.0pt;font-family:"Verdana","sans-serif""><u></u><u></u></span></b></pre><p class="MsoNormal" align="center" style="text-align:center"><span style="font-size:10.0pt;font-family:"Verdana","sans-serif";color:black"> </span><span style="font-size:12.0pt;font-family:"Times New Roman","serif""><u></u><u></u></span></p><p class="MsoNormal" align="center" style="text-align:center"><span style="font-size:12.0pt;font-family:"Verdana","sans-serif";color:black">TIME:</span><span style="font-size:10.0pt;font-family:"Verdana","sans-serif";color:black"> </span><span style="font-size:13.5pt;font-family:"Verdana","sans-serif";color:black"> <b>3:30PM</b></span><span style="font-size:12.0pt;font-family:"Times New Roman","serif""><u></u><u></u></span></p><p class="MsoNormal" align="center" style="text-align:center"><span style="font-size:10.0pt;font-family:"Verdana","sans-serif";color:black"> </span><span style="font-size:12.0pt;font-family:"Times New Roman","serif""><u></u><u></u></span></p><p class="MsoNormal" align="center" style="text-align:center"><span style="font-size:12.0pt;font-family:"Verdana","sans-serif";color:black">LOCATION:</span><span style="font-size:10.0pt;font-family:"Verdana","sans-serif";color:black"> <b> </b></span><b><span style="font-size:13.5pt;font-family:"Verdana","sans-serif";color:black">GMCS 314</span></b><span style="font-size:12.0pt;font-family:"Times New Roman","serif""><u></u><u></u></span></p><p class="MsoNormal" align="center" style="text-align:center"><span style="font-size:10.0pt;font-family:"Verdana","sans-serif";color:black"> </span><span style="font-size:12.0pt;font-family:"Times New Roman","serif""><u></u><u></u></span></p><p class="MsoNormal" align="center" style="text-align:center"><span style="font-size:12.0pt;font-family:"Verdana","sans-serif";color:black">SPEAKER:</span><span style="font-size:13.5pt;font-family:"Verdana","sans-serif";color:black">  </span><b><span style="font-size:13.5pt;font-family:"Verdana","sans-serif"">Jamie Schiffer, Ph.D, <br>      Department of Chemistry, UC San Diego<span style="color:#1f497d"><u></u><u></u></span></span></b></p><p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Verdana","sans-serif";color:black">  </span><span style="font-size:12.0pt;font-family:"Times New Roman","serif""><u></u><u></u></span></p><p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Verdana","sans-serif";color:black">ABSTRACT:</span><span style="font-size:12.0pt;font-family:"Times New Roman","serif""><u></u><u></u></span></p><p class="m_-6175594226004111878Normal1" style="line-height:normal"><span lang="EN" style="font-size:12.0pt;font-family:"Verdana","sans-serif"">Sea-spray aerosols (SSA) represent one of the most abundant aerosols within our atmosphere, and yet the current uncertainties associated with SSA impacts on total radiative forcing are much larger than those for greenhouse gases. Recently, it has been shown that triacylglycerol lipases, hydrolytic enzymes that breakdown lipids into fatty acids, are present and active within SSA. These enzymes are highly amphiphillic and thus likely to partition to air-liquid surfaces. If lipase is present at the SSA surface, then lipase could participate in critical chemical pathways within SSA, essentially guiding the climate relevant properties of these aerosols. However, the degree to which lipases partition to air-liquid surfaces as a function of surface lipid composition, pH and surface pressure, all surface characteristics which vary between SSA particles, remains elusive. Moreover, the atomic-level structures of lipases at these surfaces, which could inform on how lipases alter SSA chemical pathways, are unknown. To uncover if lipase is present at SSA surfaces and determine the structure of lipase at these surfaces, surface adsorption isotherms of lipase injected into Langmuir monolayers of lipids were interpreted in the context of microseconds of all-atom molecular dynamics simulations of lipase imbedded in SSA-relevant surfaces. At this talk, the findings from this collaborative study will be presented and multiscale models for future study will be considered for studying lipase at SSA surfaces</span><span lang="EN" style="font-size:12.0pt;font-family:"Times New Roman","serif"">. <b><u></u><u></u></b></span></p><p class="MsoNormal" align="center" style="text-align:center"><span lang="EN" style="font-size:12.0pt;font-family:"Verdana","sans-serif""><u></u> <u></u></span></p><p class="MsoNormal"><span style="font-size:9.5pt;font-family:"Verdana","sans-serif";color:black">HOST: </span><span style="font-size:10.0pt;font-family:"Verdana","sans-serif"">Andrew Cooksy</span><span style="font-size:12.0pt;font-family:"Times New Roman","serif""><u></u><u></u></span></p><p class="MsoNormal"><span style="font-size:9.5pt;font-family:"Verdana","sans-serif";color:black"> </span><span style="font-size:12.0pt;font-family:"Times New Roman","serif""><u></u><u></u></span></p><p class="MsoNormal"><span style="font-size:9.5pt;font-family:"Verdana","sans-serif";color:black">Dr. Jose E. Castillo<br>Director/Professor<br>Computational Science Research Center<br>5500 Campanile Drive<br>San Diego State University<br>San Diego, CA  92182-1245<br>(619) 59407205/3430, FAX <a href="tel:(619)%20594-2459" value="+16195942459" target="_blank">(619) 594-2459</a></span><span style="font-size:12.0pt;font-family:"Times New Roman","serif""><u></u><u></u></span></p><p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Times New Roman","serif""><u></u> <u></u></span></p></div></div><br>______________________________<wbr>_________________<br>
SDSU Computational Science Research Center<br>
Mailing List<br></div><br><br clear="all"><div><br></div>-- <br><div class="gmail_signature" data-smartmail="gmail_signature">







<p>Jose E. Castillo  Ph.D.</p><p>Director / Professor </p>
<p>Computational Science Research Center</p>
<p>5500 Campanile Dr</p>
<p>San Diego State University</p>
<p>San Diego CA 92182-1245</p>
<p>619 5947205/3430, Fax 619-594-2459</p><p> <a href="http://www.csrc.sdsu.edu/mimetic-book/" target="_blank">http://www.csrc.sdsu.edu/mimetic-book/</a></p></div>
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