[Faculty] Fwd: [CSRC.COLLOQUIUM] "An Integrative Approach to Understanding Myosin-Based Heart Disease"

[Jose Castillo]

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DATE:
*Friday, July 24, 2020*



TITLE:

*An Integrative Approach to Understanding Myosin-Based Heart Disease*


TIME:
*3:00-4:00PM*




LOCATION:
Join Zoom Meeting -  *https://SDSU.zoom.us/j/96847180420*
<https://sdsu.zoom.us/j/96847180420>



SPEAKER/BIO:

*Dr. **Sanford Bernstein, Department of Biology, San Diego State University*





ABSTRACT:

Mutations in the molecular motor protein myosin can cause either dilated
(enlarged heart chambers) or hypertrophic (excess tissue growth) cardiac
disease in humans. Using our *Drosophila melanogaster* (fruit fly) model
system, we are studying the mechanistic basis of such cardiomyopathy
mutations in skeletal and heart muscles. Analyses of the isolated mutant
myosin molecules yield insights at the atomic, biochemical and molecular
motility levels. Microscopy studies provide knowledge as to structural
aberrations in the repeating sarcomere units essential to muscle
contraction. Studies at the muscle fiber and organ levels define mechanical
and physiological defects. Overall, we find that under-functional myosin
produces dilated cardiomyopathy phenotypes, whereas increased myosin
functionality yields hypertrophic cardiomyopathy.




Host: Jose Castillo

Note: Videos of previous colloquium talks can be seen on the CSRC website
in the colloquium archive section or on the CSRC YouTube page here
<https://www.youtube.com/channel/UCN0ZEztlmyDqG2pm-Rle_Eg/feed>.


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