<div dir="ltr"><div class="gmail_quote"><div dir="ltr" class="gmail_attr"><br></div><br><br><div dir="ltr"><p style="text-align:center;clear:both"><img src="cid:28df3c14-a628-4416-a428-ca91987b28fc" alt="SDSU_CSRC Logo.jpg" style="margin-left:1em;margin-right:1em"></p><p class="MsoNormal" align="center" style="line-height:normal;color:rgba(0,0,0,0.87);font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;font-size:14px;text-align:center"><span style="color:black"><font face="verdana, sans-serif"><br><br><br><br>DATE:</font></span><font face="verdana, sans-serif"><span style="font-size:10pt;color:black"> </span><span style="font-size:13.5pt;color:black"> <br></span><b><font size="4">Friday, July 24, 2020</font></b></font></p><p class="MsoNormal" align="center" style="line-height:normal;color:rgba(0,0,0,0.87);font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;font-size:14px;text-align:center"><b><span style="font-size:18pt"><font face="verdana, sans-serif"><br></font></span></b></p><p class="MsoNormal" align="center" style="line-height:normal;color:rgba(0,0,0,0.87);font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;font-size:14px;text-align:center"><font face="verdana, sans-serif"><span style="font-size:10pt;color:black"></span></font></p><p class="MsoNormal" align="center" style="line-height:normal;color:rgba(0,0,0,0.87);font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;font-size:14px;text-align:center"><span style="color:black"><font face="verdana, sans-serif"><br></font></span></p><div dir="ltr" style="color:rgba(0,0,0,0.87)"><p class="MsoNormal" align="center" style="margin-top:1em;margin-bottom:1em;line-height:normal;font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;text-align:center"><font face="verdana, sans-serif"><span style="font-size:10pt;color:black"></span></font></p><p class="MsoNormal" align="center" style="margin-top:1em;margin-bottom:1em;line-height:normal;font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;text-align:center"><font face="verdana, sans-serif"><span style="color:black"></span></font></p><p class="MsoNormal" align="center" style="margin-top:1em;margin-bottom:1em;line-height:normal;font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;text-align:center"><font face="verdana, sans-serif"><span style="color:black">TITLE:</span><span style="font-size:10pt;color:black"><br></span></font></p><p class="MsoNormal" align="center" style="margin-top:1em;margin-bottom:1em;line-height:normal;font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;text-align:center"><font face="verdana, sans-serif"><span style="font-size:10pt;color:black"></span></font></p><p class="MsoNormal" align="center" style="margin-top:1em;margin-bottom:1em;line-height:normal;font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;text-align:center"><font size="6" face="verdana, sans-serif"></font></p><p class="MsoNormal" align="center" style="margin-top:1em;margin-bottom:1em;line-height:normal;font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;text-align:center"><font size="6" face="verdana, sans-serif"><b><span style="background-image:none;background-position:0% 0%;background-repeat:repeat"></span></b></font></p><div style="text-align:center"><p class="MsoNormal"><font face="verdana, sans-serif" size="4"><b>An Integrative Approach to Understanding Myosin-Based Heart
Disease</b> </font><u></u><u></u></p></div><div style="font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;text-align:center"><font face="verdana, sans-serif"><font size="6"><b><br></b></font><font size="6"><b></b></font></font><p class="MsoNormal" style="margin-top:1em;margin-bottom:1em;line-height:normal"><b><font face="verdana, sans-serif"><span style="font-size:11pt;color:black"></span></font></b></p><font face="verdana, sans-serif"><font size="6"><b></b></font><font size="6"><b><span style="font-size:12pt"></span></b></font><font size="6"><b></b></font><font size="6"><b><span style="font-size:11pt"></span></b></font></font></div><p class="MsoNormal" align="center" style="margin-top:1em;margin-bottom:1em;line-height:normal;font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;text-align:center"><font face="verdana, sans-serif"><span style="color:black"></span></font></p><p class="MsoNormal" align="center" style="margin-top:1em;margin-bottom:1em;line-height:normal;font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;text-align:center"><font face="verdana, sans-serif"><span style="color:black"></span></font></p><p class="MsoNormal" align="center" style="margin-top:1em;margin-bottom:1em;line-height:normal;font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;text-align:center"><span style="color:black"><font face="verdana, sans-serif"><br></font></span></p><p class="MsoNormal" align="center" style="margin-top:1em;margin-bottom:1em;line-height:normal;font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;text-align:center"><font face="verdana, sans-serif"><span style="color:black">TIME:</span><span style="font-size:10pt;color:black"> </span><span style="font-size:13.5pt;color:black"> <br></span><b><font size="4">3:00-4:00PM</font></b></font></p><p class="MsoNormal" align="center" style="margin-top:1em;margin-bottom:1em;line-height:normal;font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;text-align:center"><font face="verdana, sans-serif"><br><b><span style="font-size:18pt"><span style="color:black"></span></span></b></font></p><p class="MsoNormal" align="center" style="margin-top:1em;margin-bottom:1em;line-height:normal;font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;text-align:center"><span style="font-size:10pt;color:black"><font face="verdana, sans-serif"> </font></span></p><p class="MsoNormal" align="center" style="margin-top:1em;margin-bottom:1em;line-height:normal;font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;text-align:center"><font face="verdana, sans-serif"><span style="color:black">LOCATION:<br></span><font size="4" style="font-weight:bold"><span style="color:black">Join Zoom Meeting - </span></font><a href="https://sdsu.zoom.us/j/96847180420" title="
https://SDSU.zoom.us/j/96847180420" rel="nofollow" style="color:rgb(85,34,136);text-align:left;line-height:21px" target="_blank"><font size="4"><b>https://SDSU.zoom.us/j/96847180420</b></font></a><font size="4"><font color="#000000"><b> </b><br></font></font><span style="font-weight:bold"><font size="4"><br></font></span></font></p><p class="MsoNormal" align="center" style="margin-top:1em;margin-bottom:1em;line-height:normal;font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;text-align:center"><span style="font-size:10pt;color:black"><font face="verdana, sans-serif"> </font></span></p><p class="MsoNormal" align="center" style="margin-top:1em;margin-bottom:1em;line-height:normal;font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;text-align:center"><font face="verdana, sans-serif"><span style="color:black"></span></font></p><p class="MsoNormal" align="center" style="margin-top:1em;margin-bottom:1em;line-height:normal;font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;text-align:center"><font face="verdana, sans-serif"><span style="color:black">SPEAKER/BIO:</span><span style="font-size:13.5pt;color:black"> </span></font></p><p class="MsoNormal" align="center" style="margin-top:1em;margin-bottom:1em;line-height:normal;text-align:center"><span style="font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;color:rgb(0,0,0);text-align:left"><font face="verdana, sans-serif" size="4"><b>Dr. </b></font></span><font face="verdana, sans-serif"><span style="color:rgb(0,0,0)"><font size="4"><b>Sanford Bernstein, Department of Biology, San Diego State University</b></font></span><br></font></p><p class="MsoNormal" align="center" style="margin-top:1em;margin-bottom:1em;line-height:normal;font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;text-align:center"><font size="4" face="verdana, sans-serif"><b><b><span style="font-size:18pt"><span style="color:black"></span></span></b></b></font></p><p class="MsoNormal" align="center" style="margin-top:1em;margin-bottom:1em;line-height:normal;font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;text-align:center"><b><font face="verdana, sans-serif"><span style="font-size:18pt"></span></font></b></p><p class="MsoNormal" align="center" style="margin-top:1em;margin-bottom:1em;line-height:normal;font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;text-align:center"><span style="color:black"><font face="verdana, sans-serif"> </font></span></p><p class="MsoNormal" style="margin-top:1em;margin-bottom:1em;line-height:normal;font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif"><font size="2" face="verdana, sans-serif"><span style="color:black"><br></span></font></p><p class="MsoNormal" style="margin-top:1em;margin-bottom:1em;line-height:normal;font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif"><font size="2" face="verdana, sans-serif"><span style="color:black"><br></span></font></p><p class="MsoNormal" style="margin-top:1em;margin-bottom:1em;line-height:normal;font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;text-align:center"><span style="color:black"><font size="2" face="verdana, sans-serif">ABSTRACT:</font></span></p></div><div dir="ltr" style="color:rgba(0,0,0,0.87);font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;font-size:14px"><font face="verdana, sans-serif"><br></font></div><div dir="ltr" style="color:rgba(0,0,0,0.87)"><p class="MsoNormal"><font face="verdana, sans-serif" size="4">Mutations in the molecular motor protein myosin can cause
either dilated (enlarged heart chambers) or hypertrophic (excess tissue growth)
cardiac disease in humans. Using our <i>Drosophila melanogaster</i> (fruit
fly) model system, we are studying the mechanistic basis of such cardiomyopathy
mutations in skeletal and heart muscles. Analyses of the isolated mutant myosin
molecules yield insights at the atomic, biochemical and molecular motility
levels. Microscopy studies provide knowledge as to structural aberrations in
the repeating sarcomere units essential to muscle contraction. Studies at the
muscle fiber and organ levels define mechanical and physiological defects.
Overall, we find that under-functional myosin produces dilated cardiomyopathy
phenotypes, whereas increased myosin functionality yields hypertrophic
cardiomyopathy. </font><u></u><u></u></p><font face="verdana, sans-serif"><br></font></div><div dir="ltr" style="color:rgba(0,0,0,0.87);font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;font-size:14px"><font size="4" face="verdana, sans-serif"> <br></font></div><div dir="ltr" style="color:rgba(0,0,0,0.87);font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;font-size:14px"><font size="4" face="verdana, sans-serif"><br></font><p class="MsoNormal" style="margin:0in 5.2pt 0.0001pt 0in;line-height:13.91px"><font face="verdana, sans-serif"><br></font></p><font size="4" face="verdana, sans-serif"></font></div><font face="verdana, sans-serif" style="color:rgba(0,0,0,0.87);font-size:14px"><font size="4">Host: </font><span style="color:rgb(0,0,0)"><font size="4">Jose Castillo</font></span><br></font><div style="color:rgba(0,0,0,0.87);font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;font-size:14px"><font size="4" face="verdana, sans-serif"><br></font></div><div style="color:rgba(0,0,0,0.87);font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;font-size:14px"><p class="MsoNormal" style="margin-top:1em;margin-bottom:1em;line-height:normal"><font face="verdana, sans-serif" size="4"><span style="font-weight:bold">Note:</span><span style="font-weight:bold"> </span>Videos of previous colloquium talks<span style="text-align:center"> can be seen on the CSRC website in the colloquium archive section or on the </span><a href="https://www.youtube.com/channel/UCN0ZEztlmyDqG2pm-Rle_Eg/feed" rel="nofollow" style="color:rgb(26,115,232);text-align:center" target="_blank">CSRC YouTube page here</a><span style="text-align:center">.<br><br><br></span></font></p></div></div>
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