[Faculty] Fwd: [CSRC.COLLOQUIUM] REMINDER: "A Stochastic Multiscale Model of Cardiac Muscle Biophysics and Electro-Mechanical Coupling of Virtual Patients Cohorts"

[Jose Castillo]

[image: New CSRC Logo.jpg]

DATE:  *Friday, November 1, 2019*



TITLE:

*A Stochastic Multiscale Model of Cardiac Muscle Biophysics and
Electro-Mechanical Coupling of Virtual Patients Cohorts*


TIME:  *3:30-4:30PM*




LOCATION:
*GMCS 314*




SPEAKER/BIO:



*Dr. Yasser Aboelkassem, Assistant Research Scientist, Department of
Bioengineering, UCSD*




ABSTRACT:

Sarcomeric missense mutations affect striated muscle contractility and can
lead to various types of inherited cardiac diseases such as, hypertrophic
and dilated cardiomyopathies. The majority of these mutations have found to
be distributed on residues located at the interfaces of many proteins of
the sarcomere that regulates cardiac contraction. These mutations and
post-translational modifications influence not only contraction dynamics,
but affect myofilament calcium sensitivity and alter cooperative
interactions between the sarcomere regulatory proteins. Although, several
Monte Carlo type myofilament models attempt to investigate and/or to
predict the functional effects of point mutations on sarcomere
contractility. The exact molecular-to-filament mechanism by which these
alterations provide the trigger for disease progression and remodeling is
still remaining poorly understood. In this talk, I will present a
stochastic multiscale (molecular-to-filament) myofilament model that can
describe the activation process of the thin filament during sarcomere
contraction. The model is based on the Brownian flashing ratchet theory for
the molecular scale and is using Langevin dynamics principle for the
filament scale. This model is then integrated in a finite element model of
virtual cohorts to study the electro-mechanical coupling of tissue and
organ scales. The model is then used to predict the phenotype remodeling of
cardiac function during arrhythmia and heart failure.

Bio: Dr. Yasser Aboelkassem is currently an Assistant Research Scientist in
the Department of Bioengineering at the University of California, San Diego
(UCSD). He completed his BSc in Aerospace Engineering at Cairo University.
He then obtained a MS degree in Computational Mechanics from a joint
program between Concordia-McGill Universities, Montreal, Canada. He
received his MS in Applied Mathematics and his PhD in Engineering Science,
both from Virginia Tech. He was a Postdoctoral Associate in the Department
of Biomedical Engineering and Medicine at the Johns Hopkins University, and
prior to that He was a Postdoctoral Fellow in The Department of Biomedical
Engineering at Yale University. He recently obtained his mini-MBA degree
from Rady School of Management at UCSD. Dr. Aboelkassem’s research focuses
on hemodynamics, microcirculation, and fluid transport in the human
cardiovascular system, as well as multiscale modeling of cardiac mechanics.
He uses computational and experiments tools to investigate the
relationships between the cellular and extracellular structure of cardiac
muscle and the hemodynamics, electrical, and mechanical function of the
whole heart during cardiac diseases.







Host: Ricardo Carretero, Department of Mathematics and Statistics
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