<div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div><div><div style="overflow:auto"><div style="max-height:10000px"><div dir="ltr"><p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black"><br></span></p><p style="text-align:center;clear:both"><img style="margin-left:1em;margin-right:1em" src="https://groups.google.com/a/sdsu.edu/group/csrc.colloquium/attach/17b723ed51d27/New%20CSRC%20Logo.jpg?part=0.1&view=1&authuser=0" alt="New CSRC Logo.jpg"></p><br><p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black"></span></p><p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black">DATE:</span><span style="font-size:10.0pt;font-family:"Verdana",sans-serif;color:black"> </span><span style="font-size:13.5pt;font-family:"Verdana",sans-serif;color:black"> </span><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif">Friday, November 1, 2019</span></b></p><p class="MsoNormal" style="text-align:center" align="center"><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif"><br></span></b></p><p class="MsoNormal" style="text-align:center" align="center"><span style="font-size:10.0pt;font-family:"Verdana",sans-serif;color:black"></span></p>
<p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black"><br></span></p><div dir="ltr"><p class="MsoNormal" style="text-align:center" align="center"><span style="font-size:10.0pt;font-family:"Verdana",sans-serif;color:black"></span></p>
<p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black"></span></p><p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black">TITLE:</span><span style="font-size:10.0pt;font-family:"Verdana",sans-serif;color:black"> <br></span></p><p class="MsoNormal" style="text-align:center" align="center"><span style="font-size:10.0pt;font-family:"Verdana",sans-serif;color:black"> </span></p><p class="MsoNormal" style="text-align:center" align="center"><font size="6"><span style="font-family:verdana,sans-serif"></span></font></p><p class="MsoNormal" style="text-align:center" align="center"><font size="6"><span style="font-family:verdana,sans-serif"><b><span style="background:white none repeat scroll 0% 0%"></span></b></span></font></p><div style="text-align:center"><span style="font-family:verdana,sans-serif"><font size="6"><b><span></span></b></font></span><span style="font-family:verdana,sans-serif"><font size="6"><b><span></span></b></font></span><span style="font-family:verdana,sans-serif"><font size="6"><b><span></span></b></font></span><span style="font-family:verdana,sans-serif"><font size="6"><b><span></span></b></font></span><span style="font-family:verdana,sans-serif"><font size="6"><b><span></span></b></font></span><span style="font-family:verdana,sans-serif"><font size="6"><b><span></span></b></font></span><span style="font-family:verdana,sans-serif"><font size="6"><b><span></span></b></font></span><span style="font-family:verdana,sans-serif"><font size="6"><b><span></span></b></font></span><span style="font-family:verdana,sans-serif"><font size="6"><b><span></span></b></font></span><span style="font-family:verdana,sans-serif"><font size="6"><b><span> </span></b></font></span><span style="font-family:verdana,sans-serif"><font size="6"><b><span><span><span><span>A Stochastic Multiscale Model of Cardiac Muscle Biophysics and Electro-Mechanical Coupling of Virtual Patients Cohorts</span></span></span></span></b></font></span></div><div style="text-align:center"><span style="font-family:verdana,sans-serif"><font size="6"><b><span><span><span><span><br></span></span></span></span></b></font></span><span style="font-family:verdana,sans-serif"><font size="6"><b><span><span><span>
</span></span></span></b></font></span><p class="MsoNormal" style="text-autospace:none"><b><span style="font-size:11.0pt;font-family:"Arial",sans-serif;color:black"></span></b></p>
<span style="font-family:verdana,sans-serif"><font size="6"><b><span><span><span></span></span></span></b></font></span><span style="font-family:verdana,sans-serif"><font size="6"><b><span><span><span><span style="font-size:12.0pt;font-family:"Times New Roman",serif"></span></span> </span></span></b></font></span><span style="font-family:verdana,sans-serif"><font size="6"><b><span><span></span></span></b></font></span><span style="font-family:verdana,sans-serif"><font size="6"><b><span style="font-size:11pt"></span></b> </font></span></div><p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black"></span></p>
<p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black"></span></p><p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black"><br></span></p><p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black">TIME:</span><span style="font-size:10.0pt;font-family:"Verdana",sans-serif;color:black"> </span><span style="font-size:13.5pt;font-family:"Verdana",sans-serif;color:black"> </span><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif">3:30-4:30PM</span></b></p><p class="MsoNormal" style="text-align:center" align="center"><br><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif"><span style="color:black"></span></span></b></p>
<p class="MsoNormal" style="text-align:center" align="center"><span style="font-size:10.0pt;font-family:"Verdana",sans-serif;color:black"> </span></p><p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black">LOCATION:</span><span style="font-size:10.0pt;font-family:"Verdana",sans-serif;color:black"> <b> </b></span><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif">GMCS 314<br></span></b></p><p class="MsoNormal" style="text-align:center" align="center"><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif"><br></span></b></p>
<p class="MsoNormal" style="text-align:center" align="center"><span style="font-size:10.0pt;font-family:"Verdana",sans-serif;color:black"> </span></p>
<p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black"></span></p><p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black">SPEAKER/BIO:</span><span style="font-size:13.5pt;font-family:"Verdana",sans-serif;color:black"> </span><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif"><br></span></b></p><p class="MsoNormal" style="text-align:center" align="center"><br><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif"></span></b></p><p class="MsoNormal" style="text-align:center" align="center"><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif"></span></b><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif"></span></b><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif"></span></b><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif">Dr. Yasser Aboelkassem, Assistant Research Scientist, Department of Bioengineering, UCSD<br></span></b><font size="4"><span style="font-family:verdana,sans-serif"><b><span><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif"><span style="color:black"></span></span></b></span><span></span></b></span></font></p><p class="MsoNormal" style="text-align:center" align="center"><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif"></span></b></p>
<p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black"> </span></p>
<p class="MsoNormal"><font size="2"><span style="font-family:"Verdana",sans-serif;color:black"><br></span></font></p><p class="MsoNormal" style="text-align:left"><font size="4"><span style="font-family:"Verdana",sans-serif;color:black">ABSTRACT:</span></font></p><font size="4">
</font><p class="MsoNormal" style="margin-top:0in;margin-right:5.2pt;margin-bottom:0in;margin-left:0in;margin-bottom:.0001pt;line-height:107%">
</p><p class="MsoNormal" style="text-autospace:none"><span style="font-size:11.0pt;font-family:"Arial",sans-serif;color:black"><span style="font-family:verdana,sans-serif"><font size="4"><span style="font-family:arial,sans-serif">
</span></font></span></span></p><p class="MsoNormal" style="text-autospace:none">
</p><font size="4"><span style="font-family:verdana,sans-serif"><span>Sarcomeric missense
mutations affect striated muscle contractility and can lead to various
types of inherited cardiac diseases such as, hypertrophic and dilated
cardiomyopathies. The majority of these mutations have found to be
distributed on residues located at the interfaces of many proteins of
the sarcomere that regulates cardiac contraction. These mutations and
post-translational modifications influence not only contraction
dynamics, but affect myofilament calcium sensitivity and alter
cooperative interactions between the sarcomere regulatory proteins.
Although, several Monte Carlo type myofilament models attempt to
investigate and/or to predict the functional effects of point mutations
on sarcomere contractility. The exact molecular-to-filament mechanism by
which these alterations provide the trigger for disease progression and
remodeling is still remaining poorly understood.
In this talk, I will present a stochastic multiscale
(molecular-to-filament) myofilament model that can describe the
activation process of the thin filament during sarcomere contraction.
The model is based on the Brownian flashing ratchet theory for the
molecular scale and is using Langevin dynamics principle for the
filament scale. This model is then integrated in a finite element model
of virtual cohorts to study the electro-mechanical coupling of tissue
and organ scales. The model is then used to predict the phenotype
remodeling of cardiac function during arrhythmia and heart failure. <br></span></span></font></div><div dir="ltr"><font size="4"><span style="font-family:verdana,sans-serif"><span><br></span></span></font></div><div dir="ltr"><font size="4"><span style="font-family:verdana,sans-serif"><span>Bio: Dr. Yasser Aboelkassem is currently an Assistant Research
Scientist in the Department of Bioengineering at the University of
California, San Diego (UCSD). He completed his BSc in Aerospace
Engineering at Cairo University. He then obtained a MS degree in
Computational Mechanics from a joint program between Concordia-McGill
Universities, Montreal, Canada. He received his MS in Applied
Mathematics and his PhD in Engineering Science, both from Virginia Tech.
He was a Postdoctoral Associate in the Department of Biomedical
Engineering and Medicine at the Johns Hopkins University, and prior to
that He was a Postdoctoral Fellow in The Department of Biomedical
Engineering at Yale University. He recently obtained his mini-MBA degree
from Rady School of Management at UCSD.
Dr. Aboelkassem’s research focuses on hemodynamics, microcirculation,
and fluid transport in the human cardiovascular system, as well as
multiscale modeling of cardiac mechanics. He uses computational and
experiments tools to investigate the relationships between the cellular
and extracellular structure of cardiac muscle and the hemodynamics,
electrical, and mechanical function of the whole heart during cardiac
diseases.</span><span style="color:black"><span> </span><span> <br></span></span>
<span> </span></span></font><p class="MsoNormal" style="margin-top:0in;margin-right:5.2pt;margin-bottom:0in;margin-left:0in;margin-bottom:.0001pt;line-height:107%"><br>
</p><span style="font-family:arial,sans-serif"><font size="4">
</font></span><p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:10.0pt"><span style="font-family:arial,sans-serif"><font size="4"><span> </span></font></span></p></div><br><div dir="ltr"><font size="2"><span style="font-family:verdana,sans-serif"><span style="font-family:"Verdana",sans-serif;color:black"></span></span></font></div><br><div dir="ltr"><br><font size="4"><span style="font-family:verdana,sans-serif"></span><span style="font-family:verdana,sans-serif"></span></font></div><font size="4"><span style="font-family:verdana,sans-serif">Host: Ricardo Carretero, Department of Mathematics and Statistics<br></span></font></div></div></div></div> <div> <div> <div> <div style="display:inline-block"> </div> <div><div id="m_-789280190834763054q_reply">Click here to <span>Reply</span></div></div> </div> </div> </div></div></div>
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