<div dir="ltr"><br clear="all"><div><div dir="ltr" class="gmail_signature" data-smartmail="gmail_signature"><div dir="ltr"><div><div dir="ltr"><div><div dir="ltr"><div><br></div></div></div></div></div></div></div></div><div class="gmail_quote"><br><br><div dir="ltr"><p style="text-align:center;clear:both"><img src="cid:bfcf96d0-d9a9-4296-8659-f2ba1c5d74d0" alt="SDSU_CSRC Logo.jpg" style="margin-left:1em;margin-right:1em"></p><p class="MsoNormal" align="center" style="line-height:normal;color:rgba(0,0,0,0.87);font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;font-size:14px;text-align:center"><span style="color:black"><font face="verdana, sans-serif"><br></font></span></p><p class="MsoNormal" align="center" style="line-height:normal;color:rgba(0,0,0,0.87);font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;font-size:14px;text-align:center"><span style="color:black"><font face="verdana, sans-serif"><br></font></span></p><p class="MsoNormal" align="center" style="line-height:normal;color:rgba(0,0,0,0.87);font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;font-size:14px;text-align:center"><span style="color:black"><font face="verdana, sans-serif"><br></font></span></p><p class="MsoNormal" align="center" style="line-height:normal;color:rgba(0,0,0,0.87);font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;font-size:14px;text-align:center"><span style="color:black"><font face="verdana, sans-serif"><br>DATE:</font></span><font face="verdana, sans-serif"><span style="font-size:10pt;color:black"> </span><span style="font-size:13.5pt;color:black"> <br></span><b><font size="4">Friday, September 11, 2020</font></b></font></p><p class="MsoNormal" align="center" style="line-height:normal;color:rgba(0,0,0,0.87);font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;font-size:14px;text-align:center"><b><span style="font-size:18pt"><font face="verdana, sans-serif"><br></font></span></b></p><p class="MsoNormal" align="center" style="line-height:normal;color:rgba(0,0,0,0.87);font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;font-size:14px;text-align:center"><font face="verdana, sans-serif"><span style="font-size:10pt;color:black"></span></font></p><p class="MsoNormal" align="center" style="line-height:normal;color:rgba(0,0,0,0.87);font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;font-size:14px;text-align:center"><span style="color:black"><font face="verdana, sans-serif"><br></font></span></p><div dir="ltr" style="color:rgba(0,0,0,0.87)"><p class="MsoNormal" align="center" style="margin-top:1em;margin-bottom:1em;line-height:normal;font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;text-align:center"><font face="verdana, sans-serif"><span style="font-size:10pt;color:black"></span></font></p><p class="MsoNormal" align="center" style="margin-top:1em;margin-bottom:1em;line-height:normal;font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;text-align:center"><font face="verdana, sans-serif"><span style="color:black"></span></font></p><p class="MsoNormal" align="center" style="margin-top:1em;margin-bottom:1em;line-height:normal;font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;text-align:center"><font face="verdana, sans-serif"><span style="color:black">TITLE:</span><span style="font-size:10pt;color:black"><br></span></font></p><p class="MsoNormal" align="center" style="margin-top:1em;margin-bottom:1em;line-height:normal;font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;text-align:center"><font face="verdana, sans-serif"><span style="font-size:10pt;color:black"></span></font></p><p class="MsoNormal" align="center" style="margin-top:1em;margin-bottom:1em;line-height:normal;font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;text-align:center"><font size="6" face="verdana, sans-serif"></font></p><p class="MsoNormal" align="center" style="margin-top:1em;margin-bottom:1em;line-height:normal;font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;text-align:center"><font size="6" face="verdana, sans-serif"><b><span style="background-image:none;background-position:0% 0%;background-repeat:repeat"></span></b></font></p><div style="text-align:center"><p class="MsoNormal" align="center"><b><font face="verdana, sans-serif" size="4">Mathematical
Models Predict Ligand Expression Pattern in Murine Lungs </font><u></u><u></u></b></p></div><div style="font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;text-align:center"><font face="verdana, sans-serif"><font size="6"><b><br></b></font><font size="6"><b></b></font></font><p class="MsoNormal" style="margin-top:1em;margin-bottom:1em;line-height:normal"><b><font face="verdana, sans-serif"><span style="font-size:11pt;color:black"></span></font></b></p><font face="verdana, sans-serif"><font size="6"><b></b></font><font size="6"><b><span style="font-size:12pt"></span></b></font><font size="6"><b></b></font><font size="6"><b><span style="font-size:11pt"></span></b></font></font></div><p class="MsoNormal" align="center" style="margin-top:1em;margin-bottom:1em;line-height:normal;font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;text-align:center"><font face="verdana, sans-serif"><span style="color:black"></span></font></p><p class="MsoNormal" align="center" style="margin-top:1em;margin-bottom:1em;line-height:normal;font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;text-align:center"><font face="verdana, sans-serif"><span style="color:black"></span></font></p><p class="MsoNormal" align="center" style="margin-top:1em;margin-bottom:1em;line-height:normal;font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;text-align:center"><span style="color:black"><font face="verdana, sans-serif"><br></font></span></p><p class="MsoNormal" align="center" style="margin-top:1em;margin-bottom:1em;line-height:normal;font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;text-align:center"><font face="verdana, sans-serif"><span style="color:black">TIME:</span><span style="font-size:10pt;color:black"> </span><span style="font-size:13.5pt;color:black"> <br></span><b><font size="4">3:00-4:00PM</font></b></font></p><p class="MsoNormal" align="center" style="margin-top:1em;margin-bottom:1em;line-height:normal;font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;text-align:center"><font face="verdana, sans-serif"><br><b><span style="font-size:18pt"><span style="color:black"></span></span></b></font></p><p class="MsoNormal" align="center" style="margin-top:1em;margin-bottom:1em;line-height:normal;font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;text-align:center"><span style="font-size:10pt;color:black"><font face="verdana, sans-serif"> </font></span></p><p class="MsoNormal" align="center" style="margin-top:1em;margin-bottom:1em;line-height:normal;text-align:center"><font style="font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif"><span style="color:black">LOCATION:<br></span><font size="4" style="font-weight:bold"><span style="color:black">Join Zoom Meeting - </span></font></font><a href="https://sdsu.zoom.us/j/91071174391" title="https://SDSU.zoom.us/j/91071174391" target="_blank"><font face="verdana, sans-serif" size="4"><b>https://SDSU.zoom.us/j/91071174391</b></font></a><font style="font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif"><font size="4"><font color="#000000"><br></font></font><span style="font-weight:bold"><font size="4"><br></font></span></font></p><p class="MsoNormal" align="center" style="margin-top:1em;margin-bottom:1em;line-height:normal;font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;text-align:center"><span style="font-size:10pt;color:black"><font face="verdana, sans-serif"> </font></span></p><p class="MsoNormal" align="center" style="margin-top:1em;margin-bottom:1em;line-height:normal;font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;text-align:center"><font face="verdana, sans-serif"><span style="color:black"></span></font></p><p class="MsoNormal" align="center" style="margin-top:1em;margin-bottom:1em;line-height:normal;font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;text-align:center"><font face="verdana, sans-serif"><span style="color:black">SPEAKER/BIO:</span><span style="font-size:13.5pt;color:black"> </span></font></p><p class="MsoNormal" align="center" style="margin-top:1em;margin-bottom:1em;line-height:normal;text-align:center"><font face="verdana, sans-serif" size="4"><b>Dr. Uduak George, Mathematics and Statistics, San Diego State University </b></font> <font face="verdana, sans-serif"><br></font></p><p class="MsoNormal" align="center" style="margin-top:1em;margin-bottom:1em;line-height:normal;font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;text-align:center"><font size="4" face="verdana, sans-serif"><b><b><span style="font-size:18pt"><span style="color:black"></span></span></b></b></font></p><p class="MsoNormal" align="center" style="margin-top:1em;margin-bottom:1em;line-height:normal;font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;text-align:center"><b><font face="verdana, sans-serif"><span style="font-size:18pt"></span></font></b></p><p class="MsoNormal" align="center" style="margin-top:1em;margin-bottom:1em;line-height:normal;font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;text-align:center"><span style="color:black"><font face="verdana, sans-serif"> </font></span></p><p class="MsoNormal" style="margin-top:1em;margin-bottom:1em;line-height:normal;font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif"><font size="2" face="verdana, sans-serif"><span style="color:black"><br></span></font></p><p class="MsoNormal" style="margin-top:1em;margin-bottom:1em;line-height:normal;font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif"><font size="2" face="verdana, sans-serif"><span style="color:black"><br></span></font></p><p class="MsoNormal" style="margin-top:1em;margin-bottom:1em;line-height:normal;font-size:14px;font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;text-align:center"><span style="color:black"><font size="2" face="verdana, sans-serif">ABSTRACT:</font></span></p></div><div dir="ltr" style="color:rgba(0,0,0,0.87);font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;font-size:14px"><font face="verdana, sans-serif"><br></font></div><div><div></div></div><div dir="ltr" style="color:rgba(0,0,0,0.87)"><span style="color:rgb(34,34,34)"><font face="verdana, sans-serif" size="4">Lung development is a highly stereotyped process
that is regulated by molecular factors. Ligands such as fibroblast growth
factor 10 (Fgf10) play critical roles in lung development. Fgf10 controls the
development of the branching epithelial structures that form the future
airways. Mice that do not express Fgf10 exhibit severe lung abnormalities. The
pattern of Fgf10 expression increases in complexity during development. Disruption
of the spatiotemporal expression of Fgf10 causes lung abnormalities. Understanding
the temporal and spatial regulation of Fgf10 expression is challenging because
of the complex nature of lung development. Mathematical modeling is a powerful tool
for unraveling the dynamics of Fgf10 expression. In this talk, I will present the
new mathematical models we have developed to study Fgf10 expression pattern. I
will also present new findings from the model simulations that for the first
time identifies lung size as a regulator of the complexity of Fgf10 patterning.</font></span><font face="verdana, sans-serif" size="4"><span style="color:rgb(34,34,34)"> </span><span style="color:rgb(34,34,34)"> </span></font><span style="font-family:"Times New Roman",serif;color:rgb(34,34,34)"> </span><font face="verdana, sans-serif" size="4"> </font><font face="verdana, sans-serif" size="4"><br></font><font face="verdana, sans-serif"><br></font></div><div dir="ltr" style="color:rgba(0,0,0,0.87);font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;font-size:14px"><font size="4" face="verdana, sans-serif"> <br></font></div><div dir="ltr" style="color:rgba(0,0,0,0.87);font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;font-size:14px"><font size="4" face="verdana, sans-serif"><br></font><p class="MsoNormal" style="margin:0in 5.2pt 0.0001pt 0in;line-height:13.91px"><font face="verdana, sans-serif"><br></font></p><font size="4" face="verdana, sans-serif"></font></div><font face="verdana, sans-serif" style="font-size:14px"><font size="4"><font color="#000000">Host:</font><font color="rgba(0, 0, 0, 0.870588235294118)"> </font><font color="#000000">Jose Castillo</font></font><br></font><div style="color:rgba(0,0,0,0.87);font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;font-size:14px"><font size="4" face="verdana, sans-serif"><br></font></div><div style="color:rgba(0,0,0,0.87);font-family:Roboto,RobotoDraft,Helvetica,Arial,sans-serif;font-size:14px"><p class="MsoNormal" style="margin-top:1em;margin-bottom:1em;line-height:normal"><font face="verdana, sans-serif" size="4"><span style="font-weight:bold">Note:</span><span style="font-weight:bold"> </span>Videos of previous colloquium talks<span style="text-align:center"> can be seen on the CSRC website in the colloquium archive section or on the </span><a href="https://www.youtube.com/channel/UCN0ZEztlmyDqG2pm-Rle_Eg/feed" rel="nofollow" style="color:rgb(26,115,232);text-align:center" target="_blank">CSRC YouTube page here</a><span style="text-align:center">.</span></font></p><p class="MsoNormal" style="margin-top:1em;margin-bottom:1em;line-height:normal"><font face="verdana, sans-serif" size="4"><span style="text-align:center"><br></span></font></p><p class="MsoNormal" style="margin-top:1em;margin-bottom:1em;line-height:normal"><font face="verdana, sans-serif" size="4"><span style="text-align:center"><br></span></font></p><p class="MsoNormal" style="margin-top:1em;margin-bottom:1em;line-height:normal"><font face="verdana, sans-serif" size="4"><span style="text-align:center"><br></span></font></p></div></div>
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