<div dir="ltr"><br clear="all"><div><div dir="ltr" class="gmail_signature" data-smartmail="gmail_signature"><div dir="ltr"><div><div dir="ltr"><div><div dir="ltr"><div><br></div></div></div></div></div></div></div></div><div class="gmail_quote"><div dir="ltr"><p style="text-align:center;clear:both"><a href="https://lh3.googleusercontent.com/-ZPFNPh16sR0/Wt39FrXUP-I/AAAAAAAAAaw/3wQunGe20lUopmV_ggfPaDwE9cVAgVzxgCLcBGAs/s1600/image001.jpg" style="margin-left:1em;margin-right:1em" target="_blank"><img src="https://lh3.googleusercontent.com/-ZPFNPh16sR0/Wt39FrXUP-I/AAAAAAAAAaw/3wQunGe20lUopmV_ggfPaDwE9cVAgVzxgCLcBGAs/s1600/image001.jpg" border="0"></a></p><br>

<p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black"><br></span></p><p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black">DATE:</span><span style="font-size:10.0pt;font-family:"Verdana",sans-serif;color:black"> </span><span style="font-size:13.5pt;font-family:"Verdana",sans-serif;color:black"> </span><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif">Friday, September 6, 2019</span></b></p><p class="MsoNormal" style="text-align:center" align="center"><span style="font-size:10.0pt;font-family:"Verdana",sans-serif;color:black"></span></p>

<p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black"><br></span></p><div style="text-align:center"><div dir="ltr"><p class="MsoNormal" style="text-align:center" align="center"><span style="font-size:10.0pt;font-family:"Verdana",sans-serif;color:black"></span></p>

<p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black"><br></span></p><p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black">TITLE:</span><span style="font-size:10.0pt;font-family:"Verdana",sans-serif;color:black"> <br></span></p><p class="MsoNormal" style="text-align:center" align="center"><span style="font-size:10.0pt;font-family:"Verdana",sans-serif;color:black"> <br></span></p><p class="MsoNormal" style="text-align:center" align="center"><font size="6"><span style="font-family:verdana,sans-serif"></span></font></p><p class="MsoNormal" style="text-align:center" align="center"><font size="6"><span style="font-family:verdana,sans-serif"><b><span style="background:white none repeat scroll 0% 0%"></span></b></span></font></p><div style="text-align:center"><span style="font-family:verdana,sans-serif"><font size="6"><b><span></span></b></font></span><span style="font-family:verdana,sans-serif"><font size="6"><b><span></span></b></font></span><span style="font-family:verdana,sans-serif"><font size="6"><b><span></span></b></font></span><span style="font-family:verdana,sans-serif"><font size="6"><b><span></span></b></font></span><span style="font-family:verdana,sans-serif"><font size="6"><b><span></span></b></font></span><span style="font-family:verdana,sans-serif"><font size="6"><b><span></span></b></font></span><span style="font-family:verdana,sans-serif"><font size="6"><b><span></span></b></font></span><span style="font-family:verdana,sans-serif"><font size="6"><b><span></span></b></font></span><span style="font-family:verdana,sans-serif"><font size="6"><b><span></span></b></font></span><span style="font-family:verdana,sans-serif"><font size="6"><b><span> Understanding Cancer Using Mechanics</span></b></font></span><span style="font-family:verdana,sans-serif"><font size="6"><b><span><span></span> </span></b></font><br></span><span style="font-family:verdana,sans-serif"><font size="6"><b><span style="font-size:11pt"></span></b> </font></span></div><p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black"></span></p>

<p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black"><br></span></p><p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black"><br></span></p><p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black">TIME:</span><span style="font-size:10.0pt;font-family:"Verdana",sans-serif;color:black"> </span><span style="font-size:13.5pt;font-family:"Verdana",sans-serif;color:black"> </span><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif">4:00-5:00PM<span style="color:black"></span></span></b></p>

<p class="MsoNormal" style="text-align:center" align="center"><span style="font-size:10.0pt;font-family:"Verdana",sans-serif;color:black"> </span></p>

<p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black"><br></span></p><p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black">LOCATION:</span><span style="font-size:10.0pt;font-family:"Verdana",sans-serif;color:black"> <b> </b></span><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif">GMCS 314<br></span></b></p>

<p class="MsoNormal" style="text-align:center" align="center"><span style="font-size:10.0pt;font-family:"Verdana",sans-serif;color:black"> </span></p>

<p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black"><br></span></p><p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black">SPEAKER/BIO:</span><span style="font-size:13.5pt;font-family:"Verdana",sans-serif;color:black">  </span><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif"><br></span></b></p><p class="MsoNormal" style="text-align:center" align="center"><br><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif"></span></b></p><p class="MsoNormal" style="text-align:center" align="center"><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif"></span></b><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif"></span></b><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif"></span></b><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif">Dr.</span><span style="font-size:18.0pt;font-family:"Verdana",sans-serif"> </span></b><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif"></span></b><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif">Parag Katira, Assistant Professor, Department of Mechanical Engineering, SDSU<br></span></b><font size="4"><span style="font-family:verdana,sans-serif"><b><span><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif"><span style="color:black"></span></span></b></span><span></span></b></span></font></p><p class="MsoNormal" style="text-align:center" align="center"><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif"></span></b></p>

<p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black"> </span></p>

<p class="MsoNormal"><font size="2"><span style="font-family:"Verdana",sans-serif;color:black"><br></span></font></p><p class="MsoNormal" style="text-align:left"><font size="2"><span style="font-family:"Verdana",sans-serif;color:black">ABSTRACT:</span></font></p><font size="4">

</font><p class="MsoNormal" style="text-align:justify"><span style="font-family:arial,sans-serif"><font size="4">Cancer is a disease
rooted in genetic mutations that allow tumor cells to avoid normal cell death,
divide uncontrollably and modify their microenvironment to avoid being targeted
by natural immune system. Sadly, there is vast heterogeneity in the genetic and
epigenetic factors driving this cancerous behavior across cancer types, cancer
patients and even cells within the same tumor making targeted treatment
difficult and expensive. On the other hand, studies have recently identified
certain key mechanical signatures of cancer cells and tumor microenvironments
that seem to be more universal across tumors and even across cancer types. The
question still remains if and how these mechanical signatures of tumors may
influence the overall process of tumor growth and metastasis and can these be
targeted to alter the outcome of the disease. In this talk, I will present some
of our work on using mechanics based computational models to understand the
role of mechanics during various stages of tumor growth and metastasis and the
various insights gained from these models. </font></span></p><font size="4">

</font></div><div dir="ltr"><font size="4"><span style="font-family:verdana,sans-serif"><br></span></font></div><div dir="ltr"><font size="2"><span style="font-family:verdana,sans-serif"><span style="font-family:"Verdana",sans-serif;color:black"></span></span></font></div><br><div dir="ltr"><br><font size="4"><span style="font-family:verdana,sans-serif"></span><span style="font-family:verdana,sans-serif"></span></font></div><div style="text-align:left"><div style="text-align:left"><font size="4"><span style="font-family:verdana,sans-serif">Host: </span><span class="m_6610674589025228247JtukPc">Antonio Luque, Department of Mathematics & Statistics</span></font><span style="font-family:verdana,sans-serif"><font size="6"><b><span><span></span> </span></b></font></span><br></div><span style="font-family:verdana,sans-serif"></span></div><span style="font-family:verdana,sans-serif"><font size="6"><b><span style="font-size:11pt"></span></b> </font></span></div><p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black"></span></p>

<p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black"><br></span></p><p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black"><br></span></p><font size="4"><span style="font-family:verdana,sans-serif"></span></font></div>

<p></p>

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