<div dir="ltr"><br clear="all"><div><div dir="ltr" class="gmail_signature" data-smartmail="gmail_signature"><div dir="ltr"><div><div dir="ltr"><div dir="ltr"><br></div><div dir="ltr">Director/Professor<div style="font-size:small">Computational Science Research Center</div><div style="font-size:small">San Diego State University</div><div style="font-size:small">5500 Campanile Dr</div><div><span style="font-size:small">San Diego CA 92182-1245</span></div><div><a href="http://www.csrc.sdsu.edu" style="font-size:12.8px" target="_blank">www.csrc.sdsu.edu</a><br></div></div></div></div></div></div></div><br><br><div class="gmail_quote"><div dir="ltr">---------- Forwarded message ---------<br>From: <strong class="gmail_sendername" dir="auto">CSRC Colloquium</strong> <span dir="ltr"><<a href="mailto:csrc.colloquium@sdsu.edu">csrc.colloquium@sdsu.edu</a>></span><br>Date: Mon, Oct 22, 2018 at 9:00 AM<br>Subject: [CSRC.COLLOQUIUM] "Combining NMR and Computational Techniques to Elucidate the Molecular Structure and Assembly of Spider Silk"<br>To: CSRC Colloquium <<a href="mailto:csrc.colloquium@sdsu.edu">csrc.colloquium@sdsu.edu</a>><br>Cc: Karen Foehl Palmer <<a href="mailto:kfoehl@sdsu.edu">kfoehl@sdsu.edu</a>><br></div><br><br><div dir="ltr"><div><div style="overflow:auto"><div style="max-height:10000px"><div dir="ltr"><p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black"><b><font size="6">COMPUTATIONAL SCIENCE RESEARCH CENTER AND DEPARTMENT OF CHEMISTRY</font></b><br></span></p><p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black"><br></span></p><p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black"><br></span></p><p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black"><br></span></p><p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black">DATE:</span><span style="font-size:10.0pt;font-family:"Verdana",sans-serif;color:black"> </span><span style="font-size:13.5pt;font-family:"Verdana",sans-serif;color:black"> </span><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif">Friday, October 26, 2018</span></b></p>
<p class="MsoNormal" style="text-align:center" align="center"><span style="font-size:10.0pt;font-family:"Verdana",sans-serif;color:black"><br></span></p><p class="MsoNormal" style="text-align:center" align="center"><span style="font-size:10.0pt;font-family:"Verdana",sans-serif;color:black"> </span></p>
<p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black">TITLE:</span><span style="font-size:10.0pt;font-family:"Verdana",sans-serif;color:black"> <br></span></p><p class="MsoNormal" style="text-align:center" align="center"><span style="font-size:10.0pt;font-family:"Verdana",sans-serif;color:black"> <br></span></p><p class="MsoNormal" style="text-align:center" align="center"><font size="6"><span style="font-family:verdana,sans-serif"></span></font></p><p class="MsoNormal" style="text-align:center" align="center"><font size="6"><span style="font-family:verdana,sans-serif"><b><span style="background:white none repeat scroll 0% 0%"></span></b></span></font></p><div style="text-align:center"><span style="font-family:verdana,sans-serif"><font size="6"><b><span></span></b></font></span><span style="font-family:verdana,sans-serif"><font size="6"><b><span></span></b></font></span><span style="font-family:verdana,sans-serif"><font size="6"><b><span></span></b></font></span><span style="font-family:verdana,sans-serif"><font size="6"><b><span>Combining NMR and Computational Techniques to Elucidate the Molecular Structure and Assembly of Spider Silk</span></b></font><br></span><span style="font-family:verdana,sans-serif"><font size="6"><b><span style="font-size:11pt"></span></b> </font></span></div><p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black"> </span></p>
<p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black"><br></span></p><p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black">TIME:</span><span style="font-size:10.0pt;font-family:"Verdana",sans-serif;color:black"> </span><span style="font-size:13.5pt;font-family:"Verdana",sans-serif;color:black"> </span><span style="color:rgb(255,0,0)"><font size="6"><b><span style="font-family:"Verdana",sans-serif">3:30 PM</span></b></font></span></p>
<p class="MsoNormal" style="text-align:center" align="center"><span style="font-size:10.0pt;font-family:"Verdana",sans-serif;color:black"> </span></p>
<p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black">LOCATION:</span><span style="font-size:10.0pt;font-family:"Verdana",sans-serif;color:black"> <font size="6"><b> </b></font></span><span style="color:rgb(255,0,0)"><font size="6"><b><span style="font-family:"Verdana",sans-serif">GMCS 314</span></b></font></span></p>
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<p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black">SPEAKER/BIO:</span><span style="font-size:13.5pt;font-family:"Verdana",sans-serif;color:black"> </span><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif"></span></b></p><p class="MsoNormal" style="text-align:center" align="center"><font size="4"><span style="font-family:verdana,sans-serif"><b><span><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif"><span style="color:black"></span></span></b></span></b></span></font><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif"></span></b><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif">Gregory Holland and Bennett Addison, Department of Chemistry and Biochemistry, SDSU</span></b><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif"> <br></span></b><font size="4"><span style="font-family:verdana,sans-serif"><b><span><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif"><span style="color:black"></span></span></b></span><span></span></b></span></font></p><p class="MsoNormal" style="text-align:center" align="center"><b><span style="font-size:18.0pt;font-family:"Verdana",sans-serif"><br></span></b></p>
<p class="MsoNormal" style="text-align:center" align="center"><span style="font-family:"Verdana",sans-serif;color:black"> </span></p>
<p class="MsoNormal"><span style="font-family:"Verdana",sans-serif;color:black"><br></span></p><p class="MsoNormal"><span style="font-family:"Verdana",sans-serif;color:black">ABSTRACT:</span></p>
<p><font size="4"><span style="font-family:verdana,sans-serif">Over 300 million years spiders have evolved to produce six different
silks and one glue-like substance. Spider silks are comprised almost
entirely of protein and are used for a diverse range of applications
such as web construction, egg case production and wrapping prey. The
silks vary dramatically in their mechanical and physical properties with
the major ampullate silk (dragline) exhibiting a strength that exceeds
steel and a toughness greater than Kevlar while, the flagelliform silk
has an elasticity comparable to rubber. Our lab is focused on
understanding the molecular structure and dynamics of the proteins that
comprise the various spider silk fibers. It is the folded structures and
hierarchical organization of these proteins that imparts spider silks
their impressive yet, diverse mechanical and physical properties. Our
research team has been developing and applying a suite of analytical and
computational techniques including nuclear magnetic resonance (NMR),
Molecular Dynamics (MD) simulations, synchrotron X-ray diffraction (XRD)
and cryo-electron microscopy (cryo-EM) to probe secondary structure,
hydrogen-bonding, side chain dynamics, nanocrystallinity and oligomeric
protein assembly all of which are crucial to understanding spider silk
formation and the resulting fiber properties. Recently, we have focused
on understanding the protein-rich fluid within the various silk
producing glands to determine and molecular structure and dynamics prior
to fiber formation and elucidate the important biochemical triggers
responsible for converting this gel-like liquid to fibers with
unparalleled, yet diverse properties. It is our belief that a better
fundamental understanding of the spider silk protein molecular structure
and assembly process will accelerate the ability to mimic and reproduce
similar biologically inspired fibers in the laboratory.</span></font></p><font size="4"><span style="font-family:verdana,sans-serif">
</span></font><h2><font size="4"><span style="font-family:verdana,sans-serif"><span style="font-weight:normal"><span></span></span><span><span style="font-weight:normal"></span></span></span></font></h2><font size="4"><span style="font-family:verdana,sans-serif">
</span></font><h2><font size="4"><span style="font-family:verdana,sans-serif"> </span></font></h2>
<h2><span style="font-size:11.0pt;font-family:"Verdana",sans-serif;color:black;font-weight:normal">HOST:</span><span style="font-family:"Verdana",sans-serif;color:#1f497d"> </span>Andrew Cooksy</h2></div></div></div></div></div>
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