[Faculty] Fwd: [CSRC.COLLOQUIUM] "Structural Puzzles in Virology Solved with an Overarching Icosahedral Design Principle "

[Jose Castillo]

[image: SDSU_CSRC Logo.jpg]



DATE:
*Friday, October 16, 2020*



TITLE:

*Structural Puzzles in Virology Solved with an Overarching Icosahedral
Design Principle*


TIME:
*3:30-4:30PM*




LOCATION:
Join Zoom Meeting -  *https://SDSU.zoom.us/j/91071174391*
<https://sdsu.zoom.us/j/91071174391>



SPEAKER/BIO:

*Dr. Antoni Luque, Mathematics and Statistics, San Diego State University *






ABSTRACT:


Viruses have evolved protein containers with a wide spectrum of icosahedral
architectures to protect their genetic material. The geometric constraints
defining these container designs, and their implications for viral
evolution, are open problems in virology. The principle of
quasi-equivalence is currently used to predict virus architecture, but
improved imaging techniques have revealed increasing numbers of viral
outliers. In this talk, I will show that this theory is a special case of
an overarching design principle for icosahedral, as well as octahedral,
architectures that can be formulated in terms of the Archimedean lattices
and their duals. These surface structures encompass different blueprints
for capsids with the same number of structural proteins, as well as for
capsid architectures formed from a combination of minor and major capsid
proteins, and are recurrent within viral lineages. They also apply to other
icosahedral structures in nature, and offer alternative designs for
man-made materials and nanocontainers in bionanotechnology.




Host: Naveen Vaidya

Note: Videos of previous colloquium talks can be seen on the CSRC website
in the colloquium archive section or on the CSRC YouTube page here
<https://www.youtube.com/channel/UCN0ZEztlmyDqG2pm-Rle_Eg/feed>.




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