[Faculty] Fwd: [CSRC.COLLOQUIUM] "Mathematical Models of Targeted Cancer Treatments"

[Jose Castillo]

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DATE:  *Friday, October 4, 2019*



TITLE:


*Mathematical Models of Targeted Cancer Treatments*



TIME:  *3:30-4:30PM*




LOCATION:
*GMCS 314*




SPEAKER/BIO:



*Dr. Dominik Wodarz, Professor of Theoretical/Mathematical Biology,
Department of Ecology and Evolutionary Biology, University of
California-Irvine *




ABSTRACT:

The talk will discuss the use of mathematical models for understanding
targeted cancer therapies. One area of focus is the treatment of chronic
lymphocytic leukemia with tyrosine kinase inhibitors. I will explore how
mathematical approaches have helped elucidate the mechanism of action of
the targeted drug ibrutinib, and will discuss how evolutionary models,
based on patient-specific parameters, can make individualized predictions
about treatment outcomes. Another focus of the talk is the use of oncolytic
viruses to kill cancer cells and drive cancers into remission. These are
viruses that specifically infect cancer cells and spread throughout tumors.
I will discuss mathematical models applied to experimental data that
analyze virus spread in a spatially structured setting, concentrating on
the interactions of the virus with innate immune mechanisms that determine
the outcome of virus spread.





Host: Naveen Vaidya, Department of Mathematics and Statistics

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