[Faculty] Fwd: [CSRC-SDSU COLLOQUIUM]: "Disease Modeling at Within-Host and Between-Hosts Scales: HIV and Influenza as Case Studies"

[Jose Castillo]

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 DATE:  *Friday, September 15, 2017*

 TITLE:  *Disease Modeling at Within-Host and*

*Between-Hosts Scales: HIV and Influenza asCase Studies*

 TIME:   *3:30PM*

 LOCATION:  *GMCS 314*

 SPEAKER:  *Dr. Naveen K. Vaidya,*
*Department of Mathematics and Statistics, SDSU*

ABSTRACT:

Mathematical models are becoming increasingly useful in studying the
dynamics of infectious diseases, from within-host to between-hosts scales.
With HIV and influenza as case studies, I will demonstrate how modeling can
provide great insights into complex phenomena of these diseases. First, I
will present a within-host model that can help address some of the issues
related to the HIV treatments in the face of drug resistance. Our model
shows that although drug therapy cannot suppress the viral load due to
resistance, it can alter the viral fitness resulting in an increase in CD4+
T cell (immune cell) count, which should yield clinical benefits.
Furthermore, this benefit depends on the cell proliferation rate, which, in
some situations, produces sustained T-cell oscillations. Second, using a
between-hosts population model of avian influenza (AI) dynamics under
periodic environmental conditions, we formulate threshold indexes, such as
the basic reproductive number and the disease invasion threshold, which can
describe the global dynamics of AI transmission. Our results show that
time-varying environmental temperature predicts several interesting
features of AI dynamics, which are observed in real data: peak-time
variation, place-to-place variation, and seasonal double peaks (summer and
fall).



HOST: *Antoni Luque *



Dr. Jose E. Castillo
Director/Professor
Computational Science Research Center
5500 Campanile Drive
San Diego State University
San Diego, CA  92182-1245
(619) 59407205/3430, FAX (619) 594-2459

San Diego State University
5500 Campanile Drive
San Diego CA 92182
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-- 

Jose E. Castillo  Ph.D.

Director / Professor

Computational Science Research Center

5500 Campanile Dr

San Diego State University

San Diego CA 92182-1245

619 5947205/3430, Fax 619-594-2459

 http://www.csrc.sdsu.edu/mimetic-book/
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